The Minister for the Arts, The Hon Ben Franklin, is responsible to Parliament for operations of the Museum. The Museum is a statutory body of the Department of Enterprise, Investment and Trade.

The Museum is operated and maintained by the Trustees of the Museum of Applied Arts and Sciences, which is constituted as a body corporate under the Museum of Applied Arts and Sciences Act 1945 (the Museum’s Act). Under the provisions of the Act, the nine Trustees are appointed by the Governor, on the recommendation of the Minister for the Arts, for a term of up to three years, and may serve for a maximum of three full terms.